Symbiotic Bacteria Direct Expression of an Intestinal Bactericidal Lectin

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Symbiotic bacteria direct expression of an intestinal bactericidal lectin.

The mammalian intestine harbors complex societies of beneficial bacteria that are maintained in the lumen with minimal penetration of mucosal surfaces. Microbial colonization of germ-free mice triggers epithelial expression of RegIIIgamma, a secreted C-type lectin. RegIIIgamma binds intestinal bacteria but lacks the complement recruitment domains present in other microbe-binding mammalian C-typ...

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Intestinal Bactericidal Lectin Symbiotic Bacteria

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ژورنال

عنوان ژورنال: Science

سال: 2006

ISSN: 0036-8075,1095-9203

DOI: 10.1126/science.1127119